ubiquity: PKPD, PBPK, and Systems Pharmacology Modeling Tools

Complete work flow for the analysis of pharmacokinetic pharmacodynamic (PKPD), physiologically-based pharmacokinetic (PBPK) and systems pharmacology models including: creation of ordinary differential equation-based models, pooled parameter estimation, individual/population based simulations, rule-based simulations for clinical trial design and modeling assays, deployment with a customizable 'Shiny' app, and non-compartmental analysis. System-specific analysis templates can be generated and each element includes integrated reporting with 'PowerPoint' and 'Word'.

Version: 2.0.0
Depends: R (≥ 3.5.0)
Imports: deSolve, dplyr (≥ 1.0.0), digest, doParallel, flextable, foreach, ggplot2, knitr, magrittr, MASS, onbrand (≥ 1.0.1), optimx, PKNCA, pso, readxl, rmarkdown, rhandsontable, scales, stats, stringr, shiny
Suggests: GA, GGally, gridGraphics, gridExtra, grid, officer, webshot, ggrepel, rstudioapi, testthat
Published: 2021-09-03
Author: John Harrold ORCID iD [aut, cre]
Maintainer: John Harrold <john.m.harrold at gmail.com>
BugReports: https://github.com/john-harrold/ubiquity/issues
License: BSD_2_clause + file LICENSE
URL: https://ubiquity.tools/rworkflow
NeedsCompilation: no
SystemRequirements: Perl
Citation: ubiquity citation info
Materials: README NEWS
CRAN checks: ubiquity results

Documentation:

Reference manual: ubiquity.pdf
Vignettes: Deployment
Estimation
Language
Noncompartmental Analysis
Report Generation
Simulation
Titration/Rule-Based Simulations

Downloads:

Package source: ubiquity_2.0.0.tar.gz
Windows binaries: r-devel: ubiquity_2.0.0.zip, r-release: ubiquity_2.0.0.zip, r-oldrel: ubiquity_2.0.0.zip
macOS binaries: r-release (arm64): ubiquity_2.0.0.tgz, r-release (x86_64): ubiquity_2.0.0.tgz, r-oldrel: ubiquity_2.0.0.tgz
Old sources: ubiquity archive

Linking:

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